Neurobiological Mechanisms of the Interaction Between Pain and Sleep

Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective

DM Klyne, M Hall, SS Smith, MF Barbe, N Egorova-Brumley, A Serafimovska, PW Hodges, A Suraev

2026-04-01

Background Sleep, psychological wellbeing, and musculoskeletal health are more closely interconnected than previously recognised. ..

Time to wake up to the potential benefits of targeting sleep in osteoarthritis management.

Michelle Hall, Paulo Ferreira, Jillian Eyles, Gillian Hawker, Simon S Smith, Natalia Egorova-Brumley, Susan M McCurry, Jonas B Thorlund, David M Klyne

2026-03-22

Sleep disturbance is highly prevalent in people with osteoarthritis (OA) yet it is rarely considered in routine care. Emerging evi..

Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study

G Park, MH Khan, JW Andrushko, N Banaj, MR Borich, LA Boyd, A Brodtmann, TR Brown, CM Buetefisch, AB Conforto, SC Cramer, M Dimyan, M Domin, MR Donnelly, N Egorova-Brumley, ER Ermer, W Feng, F Geranmayeh, CA Hanlon, B Hordacre

2026-01-01

BackgroundStroke leads to complex chronic structural and functional brain changes that specifically affect motor outcomes. The bra..

Sex-specific effects of naturally shorter sleep on experimental pain perception

S Rouhi, AS Jordan, N Egorova-Brumley

2026-01-01

Introduction: – Experimental sleep loss has been linked to sex-specific alterations in pain perception, with women exhibiting grea..

What can speech tell us about pain?

Adrian Gonzales, Kylie Yao, Adam Vogel, Natalia Egorova-Brumley

2025-08-01

INTRODUCTION: Pain experiences are subjective and can vary significantly between individuals, yet pain is universally communicated..

Left nucleus accumbens volume is associated with poor sleep in hip osteoarthritis

N Egorova-Brumley, LB Pacheco, G Knox, L Nategh, F Dobson, M Hall

2025-07-01

Objective Reduction in the volume of the nucleus accumbens (NAc) has emerged as a promising signature of chronic pain transition, ..

The effect of depression on the peak alpha frequency as a biomarker of pain sensitivity

M Shi, LB Pacheco, N Egorova-Brumley

2025-07-01

Objective: To assess how Peak Alpha Frequency (PAF) as a neurophysiological biomarker of pain sensitivity is influenced by conditi..

What can speech tell us about pain?

Adrian Gonzales, Kylie Yao, Adam Vogel, Natalia Egorova-Brumley

2025-06-01

Painful Mondays: Exploring Weekly Sleep Variations and Pain Perception in Healthy Women—An Experimental Study

S Rouhi, N Egorova-Brumley, AS Jordan

2025-04-01

Background: Acute experimental sleep deprivation induces pain hypersensitivity, particularly in females. While the impact of extre..

Weekend sedentary behaviour and cognition three months after stroke based on the exploratory analysis of the CANVAS study

N Egorova-Brumley, MS Khlif, E Werden, L Johnson, A Brodtmann

2025-03-17

Stroke survivors experience high levels of sedentary behaviour. However, less is known about the variability in weekday-weekend pa..

Chronic sleep deficiency and its impact on pain perception in healthy females

S Rouhi, N Egorova-Brumley, AS Jordan

2025-02-01

Acute sleep deprivation in experimental studies has been shown to induce pain hypersensitivity in females. However, the impact of ..